Human sperm roll like ‘playful otters’ as they swim. A breakthrough in fertility science by researchers from Bristol and Mexico has shattered the universally accepted view of how sperm ‘swim’.
About 350 years ago, a Dutchman named Antonie van Leeuwenhoek invented the powerful new compound microscope and accidentally discovered the existence of bacteria, a groundbreaking achievement that changed the course of medicine.
Similarly, he decided to look at his ejaculate – definitely not an accident – and discovered tiny, wiggling creatures with tails he called “animalcules.”
These creatures “moved forward owing to the motion of their tails like that of a snake or an eel swimming in the water,” van Leeuwenhoek wrote to the secretary of the UK Royal Society in 1678.
The tail of a man’s sperm, he added “lashes with a snakelike movement.”
As scientists over the centuries continued to look down from above in their microscopes, there’s no doubt of what their eyes saw and recorded on film: Sperm swim by moving their tails from side to side.
Well, scientists have revealed that this is an optical illusion.
Using state-of-the-art 3D microscopy and mathematics, Dr Hermes Gadelha from the University of Bristol, Dr Gabriel Corkidi, and Dr Alberto Darszon from the Universidad Nacional Autonoma de Mexico have pioneered the reconstruction of the true movement of the sperm tail in 3D.
Using a high-speed camera capable of recording over 55,000 frames in one second, and a microscope stage with a piezoelectric device to move the sample up and down at an incredibly high rate, they were able to scan the sperm swimming freely in 3D.
The ground-breaking study, published in the journal Science Advances, reveals the sperm tail is in fact wonky and only wiggles on one side. While this should mean the sperm’s one-sided stroke would have it swimming in circles, sperm have found a clever way to adapt and swim forwards.
“Human sperm figured out if they roll as they swim, much like playful otters corkscrewing through water, their one-sided stoke would average itself out, and they would swim forwards,” said Dr. Gadelha, head of the Polymaths Laboratory at Bristol’s Department of Engineering Mathematics and an expert in the mathematics of fertility.
“The sperms’ rapid and highly synchronized spinning causes an illusion when seen from above with 2D microscopes – the tail appears to have a side-to-side symmetric movement, “like eels in water”, as described by Leeuwenhoek in the 17th century.
“However, our discovery shows sperm has developed a swimming technique to compensate for their lop-sidedness and in doing so have ingeniously solved a mathematical puzzle at a microscopic scale: by creating symmetry out of asymmetry,” said Dr. Gadelha.
“The otter-like spinning of human sperm is however complex: the sperm head spins at the same time that the sperm tail rotates around the swimming direction. This is known in physics as precession, much like when the orbits of Earth and Mars precess around the sun.”
Computer-assisted semen analysis systems in use today, both in clinics and for research, still use 2D views to look at sperm movement. Therefore, like Leeuwenhoek’s first microscope, they are still prone to this illusion of symmetry while assessing semen quality. This discovery, with its novel use of 3D microscope technology combined with mathematics, may provide fresh hope for unlocking the secrets of human reproduction.
“With over half of infertility caused by male factors, understanding the human sperm tail is fundamental to developing future diagnostic tools to identify unhealthy sperm,” adds Dr. Gadelha, whose work has previously revealed the biomechanics of sperm bendiness and the precise rhythmic tendencies that characterize how a sperm moves forward.
Dr. Corkidi and Dr. Darszon pioneered the 3D microscopy for sperm swimming.
“This was an incredible surprise, and we believe our state-of-the-art 3D microscope will unveil many more hidden secrets in nature. One day this technology will become available to clinical centers” said Dr. Corkidi.
“This discovery will revolutionize our understanding of sperm motility and its impact on natural fertilization. So little is known about the intricate environment inside the female reproductive tract and how sperm swimming impinges on fertilization. These new tools open our eyes to the amazing capabilities sperm have,” said Dr. Darszon.
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